Sequence Length Dictates Repeated CAG Folding in Three-Way Junctions
نویسندگان
چکیده
منابع مشابه
Sequence-dependent folding of DNA three-way junctions.
Three-way DNA junctions can adopt several different conformers, which differ in the coaxial stacking of the arms. These structural variants are often dominated by one conformer, which is determined by the DNA sequence. In this study we have compared several three-way DNA junctions in order to assess how the arrangement of bases around the branch point affects the conformer distribution. The res...
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We have studied a series of three-way DNA junctions containing unpaired bases on one strand at the branch-point of the junctions. The global conformation of the arms of the junctions has been analysed by means of polyacrylamide gel electrophoresis, as a function of conditions. We find that in the absence of added metal ions, all the results for all the junctions can be accounted for by extended...
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The cost of detecting asymptomatic colonic cancer with a sequence of occult blood tests by the guaiac method is investigated to determine theelfect of sequence length. The results are sensitive to the definition of a screen positive and a variety of definitions of a positive screen are investigated. It is found that additional tests, when practical, can be used elfectively to reduce the average...
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To develop advanced materials for electronic devices, it is of utmost importance to design organic building blocks with tunable functionality and to study their properties at the molecular level. For organic electronic and photovoltaic applications, the ability to vary the nature of charge carriers and so create either electron donors or acceptors is critical. Here we demonstrate that charge ca...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2011
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi101756e